韩英:女,45岁,教授、主任医师,博士生导师。1981-1986年毕业于河北医科大学医学系;1996-1998年在日本京都府立医科大学留学,从事离子通道及信号转导的研究工作。1998-2001年毕业于第四军医大学消化内科,获博士学位。博士毕业后,2002-2003年在日本东京大学药学系做博士后研究,从事药代动力学及药效学的研究工作。2000获国家自然科学基金面上项目一项,题目为“MGr1-Ag的耐药机制与离子通道及信号转导的关系”现已顺利结题。2004年获国家自然科学基金面上项目一项,项目名称为“介导结合胆红素转运新分子的克隆、鉴定及功能研究”;2009年获陕西省“3115”重大科技专项1项;负责“863”分课题、国家“十一五”科技支撑计划分课题和“973”项目子课题各一项。现任第四军医大学西京消化病院九科主任,中华医学会内科学分会常委、中华医学会肝病学分会委员。主要从事免疫性肝病发病机制和干细胞移植治疗终末期肝病的研究。2009年获军队医疗成果一等奖1项(第一完成人),近年来发表以第一作者、通讯作者共发表SCI论文10篇。
主要论文:
1. Y Han, L Yan, G Han, X Zhou, L Hong, Z Yin, X Zhang, S Wang, J Wang, A Sun, Z Liu, H Xie, K Wu, J Ding and D Fan. Controlled Trials in HBV Related Decompensate Liver Cirrhosis: Peripheral Blood Stem Cell Transplant versus G-CSF Mobilization Therapy. Cytotherapy. 2008;10(4):390-396.
2. Li Yan, Ying Han*, Jingbo Wang, Jingmei Liu, Yuanlong He, Honghong Wang and Daiming Fan. Peripheral Blood Monocytes from the Decompensated Liver Cirrhosis Could Migrate into Nude Mouse Liver with Human Hepatocyte Markers Expression. Biochem Biophys Res Commun. 2008;371(4):635-638. (*co-first author)
3. Li Yan, Ying Han, Jingbo Wang, Jingmei Liu, Liu Hong and Daiming Fan. Peripheral blood monocytes from patients with HBV related decompensated liver cirhhosis can differentiate into functional hepatocytes. American Journal of Hematology. 2007; 82(11): 949-954. (*co-first author)
4. Li Yan, Ying Han, Jingmei Liu, Jianhong Wang, Xinmin Zhou, Yuanlong He, and Daiming Fan. Therapeutic potential of peripheral blood stem cell transplantation in the cirrhotic patient caused by HBV combined with HCV. EXCLI Journal 2008; 7:13-18. (*co-first author)
5. Wang J, Han Y, Liang J, Cheng X, Yan L, Wang Y, Liu J, Luo G, Chen X, Zhao L, Zhou X, Wu K, Fan D. Effect of a novel inhibitory mAb against beta-subunit of F1F0 ATPase on HCC. Cancer Biol Ther. 2008 Nov 26;7(11). (*co-first author)
6. Yan L, Han Y*, He Y, Xie H, Liu J, Zhao L, Wang J, Gao L, Fan D. Cell Tracing Techniques in Stem Cell Transplantation. Stem Cell Rev. 2007; 3(4):265-269. (*co-first author)
7. Han Y, Shi Y, Han Z, Sun L, Fan D. Detection of potassium currents and regulation of multidrug resistance by potassium channels in human gastric cancer cells. Cell Biology International,2007; 31(7):741-7
8. Han Y, Sugiyama Y. Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice. Biol Pharm Bull. 2006; 29(5): 1032-5.
9. Y. Han, Z.G .Liu, X.M. Zhou, K.C. Wu, J. Ding, D.M. Fan. Rare acute mesenteric artery embolism: a case report. EXCLI Journal 2006; 5:42-45.
10. Jingmei Liu, Xinmin Zhou, Ying Han*, Li Yan, Jingbo Wang, Daiming Fan. Primary Biliary Cirrhosis associated with rheumatoid arthritis: two case reports in China. EXCLI Journal 2007; 6: 183-186. (*co-first author)
11. Han Y, Han ZY, Zhou XM, Shi R, Zheng Y, Shi YQ, Miao JY, Pan BR, Fan DM. Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drug-resistant sublines. World J Gastroenterol. 2002; 8(3): 441-5.
12. Hong L, Han Y, Han Y, Zhao Y, Zhang X, Qiao T, Chen Z, Fan D. Mechanisms of growth arrest by zinc ribbon domain-containing 1 (ZNRD1) in gastriccancer cells. Carcinogenesis. 2007; 28(8):1622-8.
13. Shi Y, Han Y, Wang X, Zhao Y, Ning X, Xiao B, Fan D.MGr1-Ag is associated with multidrug-resistant phenotype of gastric cancer cells. Gastric Cancer. 2002; 5(3): 154-9.
14. Hong L, Zhao Y, Han Y, Guo W, Wang J, Li X, Han Y, Fan D. Reversal of migraine symptoms by Helicobacter pylori eradication therapy in patients with hepatitis-B-related liver cirrhosis. Helicobacter. 2007; 12(4):306-8.
15. Han Z, Hong L, Han Y, Wu K, Han S, Shen H, Li C, Yao L, Qiao T, Fan D. Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. J Exp Clin Cancer Res. 2007; 26(2):261-268.
16. Hong L, Wang J, Han Y, Zhao Y, Gao J, Wang J, Han Y, Zhang X, Yan L, Zhou X, Qiao, Chen Z, Fan D. Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. Cell Biology International, 2007; 31(9): 1010-5.
17. Hong L, Wang J, Han Y, Zhao Y, Gao J, Wang J, Han Y, Zhang X, Yan L, Zhou X, Qiao T, Chen Z, Fan D. Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. Cell Biol Int. 2007; 31(9): 1010-5.
18. Hong L, Zhao Y, Wang J, Han Y, Guo W, Jin H, Zhai H, Bai F, Zhang X, Qiao T, Chen Z, Fan D. Reversal of Multidrug Resistance of Adriamycin-resistant Gastric Adenocarcinoma Cells Through the Up-regulation of DARPP-32. Dig Dis Sci. 2008; 53(1):101-7.
19. Li TT, Zhao LN, Liu ZG, Han Y, Fan DM. Regulation of apoptosis by the papillomavirus E6 oncogene. World J Gastroenterol. 2005; 11(7): 931-7.
20. Shi Y, Zhai H, Wang X, Wu H, Ning X, Han Y, Zhang D, Xiao B, Wu K, Fan D. Multidrug-resistance-associated protein MGr1-Ag is identical to the human 37-kDa laminin receptor precursor. Cell Mol Life Sci. 2002; 59(9): 1577-83.
21. Sun L, Shi Y, Guo C, Yao L, Lin T, Du J, Han Q, Han Y, Fan D. Regulation of multidrug resistance by MGr1-antigen in gastric cancer cells. Tumour Biol. 2006; 27(1):27-35.
22. Han Z, Hong L, Wu K, Han S, Shen H, Liu C, Han Y, Liu Z, Han Y, Fan D. Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA. J Exp Clin Cancer Res. 2006; 25(4):601-6.
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