丁杰,男,汉族,1952年10月生,第四军医大学西京医院内科教研室主任,西京消化病医院副院长、教授、主任医师,博士生导师。曾担任陕西省消化内镜学会主任委员、消化学会常委,现为陕西省消化内镜学会名誉主任委员、消化学会顾问、保健委员会专家、全军消化专业委员会委员。1979年毕业于第四军医大学,获医学学士学位,1986年7月获第四军医大学医学硕士学位,1991年7月获第四军医大学医学博士学位,1996年6月至1997年6月在日本京都府立医科大学留学。长期从事有关慢性胃炎、胃癌的基础与临床的研究,在胃癌早期诊断、疫苗、多药耐药、血管抑制治疗等领域取得较大成果,获国家科技进步一等奖1项、省科技进步一等奖2项、军队科技进步二等奖2项、军队医疗成果二等奖1项、省级科技进步二等奖1项。先后获得国家自然科学基金、国家“973”计划课题、国家“863”计划课题、军队科技攻关等课题10余项。获国家发明专利5项。2005年获军队院校育才奖银奖、2007年被评为全军优秀教师,1名研究生的论文被评为全军优秀硕士学位论文。在国内外专业期刊发表学术论文100余篇,其中第一作者或通讯作者文章50余篇(SCI收录10篇)。
发表的论文主要有:
1) Meng F, Dong B, Li H, Fan D, Ding J. RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer. Cancer Biol Ther. in press 8(2). 2009(Ding J is the corresponding author.)
2) Yanqi Zhang, Xueyan Guo, Shuang Han, Yu Chen, Fulin Ge, Feihu Bai, Shiren Sun, Xufeng Wei, Jie Ding, Daiming Fan. Expression and significance of TWIST basic helix-loop-helix protein overexpression in gastric cancer. Pathology. (October 2007) 39(5), pp. 470–475(Ding J is the corresponding author.)
3) Liang S*, Lin T*, Ding J, Pan Y, Dang D, Guo C, Zhi M, Zhao P, Sun L, Yao L, Liu J, Wu K, Fan D. Screening and Identification of Vascular Endothelial Cell Specific Binding Peptide in Gastric Cancer. J Mol Med. 2006 Sep;84(9):764-773(Ding J is the corresponding author.)
4) Han S, Gou C, Hong L, Liu J, ZheyiHan, Liu C, Wang J, Wu K, Ding J, Fan D. Expression and significance of Id1 helix–loop–helix protein overexpression in gastric cancer. Cancer Letters 216 (2004) 63–71. (Ding J is the corresponding author.)
5) Lin T, Liang S, Meng F, Han Q, Guo C, Sun L, Chen Y, Liu Z, Yu Z, Xie H, Ding J, Fan D. Enhanced immunogenicity and antitumor effects with heterologous prime-boost regime using vaccines based on MG7-Ag mimotope of gastric cancer. Clin Exp Immunol. 2006 May;144(2):319-25. (Ding J is the corresponding author.)
6) Guo C, Ding J, Yao L, Sun L, Lin T, Song Y, Sun L, Fan D. Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1.Int J Cancer. 2005 Aug 10;116(1):155-60. (Ding J is the corresponding author.)
7) Meng F, Ding J, Liu N, Zhang J, Shao X, Shen H, Xue Y, Xie H, Fan D Inhibition of gastric cancer angiogenesis by vector-based RNA interference for Raf-1. Cancer Biol Ther. 2005 Jan;4(1):113-7. Epub 2005 Jan 8. (Ding J is the corresponding author.)
8) Meng FP, Ding J, Yu ZC, Han QL, Guo CC, Liu N, Fan DM. Oral attenuated Salmonella typhimurium vaccine against MG7-Ag mimotope of gastric cancer. World J Gastroenterol. 2005 Mar 28;11(12):1833-6. (Ding J is the corresponding author.)
9) Zhang J, Ding J, Zhang X, Shao X, Hao Z. Regulation of Vascular Endothelial Growth Factor (VEGF) Production and Angiogenesis by Tissue Factor (TF) in SGC-7901 Gastric Cancer Cells. Cancer Biol Ther. 2005 Jul;4(7):769-772. (Ding J is the corresponding author.)
10) Liu J, Han S, Ding J, Wu K, Miao J, Fan D. COX2-related multicentric mixed-type Castleman's disease in a young man. Nat Clin Pract Oncol. 2005 Jul;2(7):370-5.
11) Liu J, Lian Z, Han S, Waye II, Wang H, Wu MC, Wu K, Ding J, Arbuthnot P, Kew M, Fan D, Feitelson MA Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma. Oncogene 2006 Feb 16;25(7):1008-1017.
12) Yin F, Du Y, Hu W, Qiao T, Ding J, Wu K, Liu Z, Fan D. Mad2beta, an alternative variant of Mad2 reducing mitotic arrest and apoptosis induced by adriamycin in gastric cancer cells. Life Sci. 2006 Feb 16;78(12):1277-86. Epub 2005 Oct 7.
13) Ji WS, Hu JL, Wu KC, Qiu JW, Han ZY, Ding J, Fan DM. Helicobacter pylori specific immune response induced by conservative flagellin linear B-cell epitope. World J Gastroenterol. 2005 Jun 21;11(23):3528-32.
14) Fan D, Zhang X, Chen X, Mou Z, Hu J, Zhou S, Ding J, Wu K Bird's-eye view on gastric cancer research of the past 25 years. J Gastroenterol Hepatol. 2005 Mar;20(3):360-5.
15) Wu KC, Li HT, Qiao TD, Li CN, Ji WS, Tian FQ, Wang X, Wang BL, Miao JY, Ding J, Fan DM Diagnosis of atrophic body gastritis in Chinese patients by measuring serum pepsinogen. Chin J Dig Dis. 2004;5(1):22-7.
16) Zhou XM, Miao JY, Yang Y, Zhao L, Wang X, Xu L, Ding J, Wu KC, Fan DM, Wang MM Clinical experience with molecular adsorbent recirculating system (MARS) in patients with drug-induced liver failure. Artif Organs. 2004 May;28(5):483-6.
17) Zhang HB, Wong BC, Zhou XM, Guo XG, Zhao SJ, Wang JH, Wu KC, Ding J, Lam SK, Fan DM Effects of somatostatin, octreotide and pitressin plus nitroglycerine on systemic and portal haemodynamics in the control of acute variceal bleeding.
18) Liu J, Hu JL, Zhang XY, Qiao TD, Chen XT, Wu KC, Ding J, Fan DM The value of MG7 antigen in predicting cancerous change in dysplastic gastric mucosa.Int J Clin Pract. 2002 Apr;56(3):169-72. |