Speaker:
Yung-Chi "Tommy" Cheng
Henry Bronson Professor of Pharmacology
Yale University School of Medicine

Title：
Integration of western and traditional Chinese medicine to fulfill the unmeet clinical needs: PHY906,a TCM formula,may serve as pan- adjuvant therapy for the treatment of cancer patients undergoing chemotherapy.

Time:  AM 8:30（pending）  November 22,2010
Location: International academic hall in Xijing Dospital of Digestive Diseases

Research Interests:
Our laboratory focuses on cancer and viral chemotherapy. We are studying the functional roles and properties of virus-specific proteins in order to design selective antiviral compounds. Some anti-HIV drugs have selective action against mitochondrial DNA synthesis that could lead to toxicity. This observation offered the opportunity to develop new antiviral drugs without such side effects and to examine the role of mitochondrial DNA synthesis in nuclear DNA synthesis. A new class of biological active nucleoside analogs, L(-)nucleosides were discovered. Drug resistance is a critical issue in cancer chemotherapy. Our laboratory is interested in exploring the mechanisms of drug resistance development, with a special emphasis on the process involved in DNA topoisomerase, targeting drugs and nucleoside analogs. The gene regulator and the inhibitors may not only have use as cancer chemotherapeutic agents, but also in controlling the development of drug resistance. To explore Chinese medicine for current clinical usage is also pursued.