聂勇战, 教育部“长江学者”特聘教授，国家杰出青年基金获得者，教育部新世纪优秀人才计划获得者，解放军总后勤部“科技新星”、博士生导师。消化内科副主任，肿瘤生物学国家重点实验室常务副主任。2002-2009年留学耶鲁大学医学院。第13届、14届国家基金委医学部二审评审专家、中华医学会消化学分会青年委员, 中华医学会消化学分会组织生物样本库协作组副组长、中国抗癌学会肿瘤转移学委员会常委、中国生物物理学会分子影像学委员会常委、中国生物化学学会蛋白质组学委员会委员、中国医药生物技术协会组织生物样本库分会委员、International Cancer Genome Consortium (ICGC)委员。担任Proteomics Clincal Application等国际国内杂志编委。陕西省重点科技创新团队带头人、全军科技创新优秀群体奖第三完成人。先后主持国家自然科学基金国际重大合作项目、“973”课题、多项自然科学基金面上项目和“十二五”国家临床规范用药平台建设等项目。主要研究方向为肝脏糖脂代谢、消化系肿瘤标志物鉴定与肿瘤转移机制。以第一作者或通讯作者在Nature Cell Bilogy、Hepatology、PLoS Genetics、Journal of Hepatology、Oncogene、Molecular & Cellular Biology、Journal of Biochemistry、Journal of Virology等相关权威杂志发表SCI论著16篇，以参与人在Cell、Nature Medicine、Proc Natl Acad Sci USA.等杂志发表SCI论著29篇。

 

1. Xia L, Mo P, Huang W, Zhang L, Wang Y, Zhu H, Tian D, Liu J, Chen Z, Zhang Y, Chen Z, Hu H, Fan D, Nie Y*, Wu K*. The TNF-a/ROS/HIF-1-induced Upregulation ofFoxMI Expression Promotes HCC Proliferation and Resistance to Apoptosis. Carcinogenesis. 2012 Nov;33(11):2250-9.

2. Zhou J, Yang J, Li K, Mo P, Feng B, Wang X, Nie Y*, Fan D*. RhoE is Associated with Relapse and Prognosis of Patients with Colorectal Cancer. Ann Surg Oncol.2012 Sep 1  . [Epub ahead of print]

3.  Xia L, Huang W, Tian D, Zhu H, Zhang Y, Hu H, Fan D, Nie Y*, Wu K*. Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma. J Hepatol. 2012 Sep;57(3):600-12.

4. Xia L, Huang W, Tian D, Zhu H, Qi X, Chen Z, Zhang Y, Hu H, Fan D, Nie Y, Wu K. Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma. Hepatology. 2012 Aug 22. doi:10.1002/hep.26029. [Epub ahead of print]

5. Yang H, Shi L, Wang BA, Liang D, Zhong C, Liu W, Nie Y, Liu J, Zhao J, Gao X,Li D, Xu GL, Li J. Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Cell. 2012 Apr 27;149(3):605-17.

6. Xia L, Tian D, Huang W, Zhu H, Wang J, Zhang Y, Hu H, Nie Y, Fan D, Wu K. Upregulation of IL-23 expression in patients with chronic hepatitis B is mediated by the HBx/ERK/NF-kB pathway. J Immunol. 2012 Jan 15;188(2):753-64.

7. Xue Z, Yan H, Li J, Liang S, Cai X, Chen X, Wu Q, Gao L, Wu K, Nie Y*, Fan D*. Identification of cancer stem cells in vincristine preconditioned SGC7901 gastric cancer cell line. J Cell Biochem. 2012 Jan;113(1):302-12.

8. Zhu H, Xia L, Zhang Y, Wang H, Xu W, Hu H, Wang J, Xin J, Gang Y, Sha S, Xu B, Fan D, Nie Y*, Wu K*. Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. PLoS One. 2012;7(2):e31431.

9. Zhou J, Li K, Gu Y, Feng B, Ren G, Zhang L, Wang Y, Nie Y*, Fan D.Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia. Biochem Biophys Res Commun. 2011 Nov 18;415(2):348-54.

10. Liang S, He L, Zhao X, Miao Y, Gu Y, Guo C, Xue Z, Dou W, Hu F, Wu K, Nie Y*, Fan D. MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer. PLoS One. 2011 Apr 18;6(4):e18409.

11. Tie J, Pan Y, Zhao L, Wu K, Liu J, Sun S, Guo X, Wang B, Gang Y, Zhang Y, Li Q, Qiao T, Zhao Q, Nie Y*, Fan D*. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet. 2010 Mar12;6(3):e1000879.

12.  Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, Samuel VT, Shulman GI. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93.

13. Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q. STAT3inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol. 2009 Apr;11(4):492-500.

14. Wu K, Nie Y, Guo C, Chen Y, Ding J, Fan D. Molecular basis of therapeutic approaches to gastric cancer. J Gastroenterol Hepatol. 2009 Jan;24(1):37-41. Review.

15. Nie Y, Hammond GL, Yang JH. Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection. J Virol. 2007 Jan;81(2):917-23.
16. Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med. 2007 Jan;13(1):89-94.

17. Nie Y, Ding L, Kao PN, Braun R, Yang JH. ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol Cell Biol. 2005 Aug;25(16):6956-63.

18. Nie Y, Zhao Q, Su Y, Yang JH. Subcellular distribution of ADAR1 isoforms is synergistically determined by three nuclear discrimination signals and a regulatory motif. J Biol Chem. 2004 Mar 26;279(13):13249-55.

19. Yang JH, Nie Y, Zhao Q, Su Y, Pypaert M, Su H, Rabinovici R. Intracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammation. J Biol Chem. 2003 Nov 14;278(46):45833-42.

20. Nie Y, Wu K, Yang J, Tian F, Li L, Chen B, Fan D. Induction of T lymphocytes  specific to human gastric cancer using HLA-A matched allogeneic gastric tumor cells. J Immunother. 2003 Sep-Oct;26(5):403-11.