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时永全,男,1973年11月出生， 1996年毕业于第四军医大学医疗系本科, 获医学学士学位。1999年和2002年在第四军医大学消化内科分别获得医学硕士学位和博士学位。2006年6月至2009年5月在加拿大多伦多大学(University of Toronto)进行博士后研究。现任第四军医大学西京消化病医院副教授、主治医师。陕西省消化病专业委员会委员兼秘书、陕西省肝病专业委员会委员。主要从事胃肠道恶性肿瘤的发病机理、早期诊断和综合治疗研究。先后负责2项国家自然 科学基金面上项目，1项国家“973”分课题。研究成果在国际专业刊物发表学术论文40余篇。2006年获陕西省科技进步一等奖1项（排名第二），2008年获国家科技进步一等奖1项（排名第四）。
主要论文：
1. Shi Y, Zhang J, Mullin M, Dong B, Alberts AS, Siminovitch KA. The mDial Formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis. J Immunol. 2009 Mar 15;182(6):3837-45.
2. Shi Y, Dong B, Miliotis H, Liu J, Alberts AS, Zhang J, Siminovitch KA. Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils. Biochem Cell Biol. 2009 Feb;87(1):207-16.
3. Zhai H, Shi Y, Jin H, Li Y, Lu Y, Chen X, Wang J, Ding L, Wang X, Fan D. Expression of CacyBP/SIP Protein in Normal and Malignant Human Tissues: An Immunohistochemical Survey. J Histochem Cytochem. 2008 Aug;56(8):765-72.
4. Zhang Y, Shi Y, Li X, Du R, Luo G, Xia L, Du W, Chen B, Zhai H, Wu K, Fan D. Proteasome inhibitor MG132 reverses multidrug resistance of gastric cancer through enhancing apoptosis and inhibiting P-gp. Cancer Biol Ther. 2008 Apr;7(4):540-6.
5. Lan M, Shi Y, Sun L, Liu L, Guo X, Lu Y, Wang J, Liang J, Fan D. KCl Depolarization Increases HIF-1 Transcriptional Activity via the Calcium-Independent Pathway in SGC7901 Gastric Cancer Cells. Tumour Biol. 2007 Jun;28(3):173-180.
6. Han Y, Shi Y, Han Z, Sun L, Fan D. Detection of potassium currents and regulation of multidrug resistance by potassium channels in human gastric cancer cells. Cell Biol Int. 2007 Jul;31(7):741-7.
7. Zhai H, Shi Y, Yu J, Hong L, Tang H, Wang J, Hu S, Bai F, Fan D. Establishment and characterization of calcyclin binding protein (CacyBP) monoclonal antibody. Hybridoma (Larchmt). 2006 Apr;25(2):91-4.
8. Lan M, Shi Y, Han Z, Hao Z, Pan Y, Liu N, Guo C, Hong L, Wang J, Qiao T, Fan D. Expression of Delayed Rectifier Potassium Channels and their Possible Roles in Proliferation of Human Gastric Cancer Cells. Cancer Biol Ther. 2005 Dec;4(12):1342-7.
9. Liu C, Shi Y, Du Y, Ning X, Liu N, Huang D, Liang J, Xue Y, Fan D. Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK. Exp Cell Res. 2005 Oct 1;309(2):410-8.
10. Shi Y, Liu Z, Zhang D, Fan D. RNA Interference: A New Therapeutic Strategy of Cancer. Cancer Biol Ther. 2005 Aug 20;4(8):830-1.
11. Du J, Shi Y, Pan Y, Jin X, Liu C, Liu N, Han Q, Lu Y, Qiao T, Fan D. Regulation of Multidrug Resistance by Ribosomal Protein L6 in Gastric Cancer Cells. Cancer Biol Ther. 2005, 4(2): 242-247.
12. Shi Y, Hu W, Yin F, Sun L, Liu C, Lan M, Fan D. Regulation of drug sensitivity of gastric cancer cells by human calcyclin-binding protein (CacyBP). Gastric Cancer. 2004;7(3):160-6.
13. Shi Y, Zhai H, Wang X, Han Z, Liu C, Lan M, Du J, Guo C, Zhang Y, Wu K, Fan D. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. Exp Cell Res. 2004 Jun 10;296(2):337-46.
14. Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D. Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein. Cancer Biol Ther. 2004 Apr;3(4):377-81. Epub 2004 Apr 17.
15. Shi Y, Zhai H, Wang X, Wu H, Ning X, Han Y, Zhang D, Xiao B, Wu K, Fan D. Multidrug-resistance-associated protein MGr1-Ag is identical to the human 37-kDa laminin receptor precursor. Cell Mol Life Sci. 2002 Sep;59(9):1577-83.
16. Shi Y, Han Y, Wang X, Zhao Y, Ning X, Xiao B, Fan D. MGr1-Ag is associated with multidrug-resistant phenotype of gastric cancer cells. Gastric Cancer. 2002;5(3):154-9.
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